Starting in the summer of 2020, the International Space Science Institute has organised the weekly on-line seminar series called “Game Changers”. After six series of weekly talks on the themes of “Missions that Changed the Game in Solar System, Astrophysics and Earth Sciences” , “Ideas and Findings about the Solar System, the Universe and our Terrestrial Environment”, “Habitability – From Cosmic to Microbial Scales”, “Viewing Earth from Space – the Changing Environment and Climate of our Planet”, and “Captivating Cosmology: From the Big Bang to Tomorrow” and the topic “Space Environmental Hazards: Mitigation and Prediction”, the webinar series continues on a monthly basis.